VMs from either VMware vSphere, Microsoft Hyper-V, Microsoft Azure or Amazon Web Services (AWS) can be protected to an Azure recovery site. Azure can be configured as both a protected site and a recovery site. Protection of Azure VMs to another Azure site/region is supported.

Failover to Azure includes the option to configure Reverse Protection during or after Failover, allowing for automated reverse replication and failback from Azure.

Zerto IT Resilience Platform (IRP) is supported for the following Azure Regions:
- Azure Government regions
- Germany (all)
- China
- All other regions