Cisco supports mixing nodes with Intel v3 and Intel v4 processors within the same storage cluster. Also M4 and M5 nodes can be mixed within the same cluster. HyperFlex Edge does not support mixed M4/M5 clusters.

Mixing of HX220c and HX240c models is not allowed inside a single storage cluster (homogenous setup).

Mixing of HX2x0c, HXAF2x0c and HXAN2x0c models is not allowed inside a single storage cluster (homogenous setup).

Multiple homogenous HyperFlex storage clusters can be used in a single vCenter environment. The current maximum is 100.

Cisco HyperFlex supports up to 8 clusters on a single HX FI Domain.