SimpliVity was founded late 2009 and began to ship its first Hyper Converged Infrastructure (HCI) solution, OmniStack (OmniStack), in 2013. The core of the SimpliVity solution is the OmniStack OS combined with OmniStack Accellerator PCIe card. In January 2017 SimpliVity was acquired by HPE. In the second quarter of 2017 HPE introduced SimpliVity on HPE ProLiant server hardware and the platform was rebranded to HPE SimpliVity 380. In July 2018 HPE extended the HPE SimpliVity product family with the HPE SimpliVity 2600 featuring software-only deduplication and compression. In June 2019 HPE once again extended the SimpliVity product family with the HPE SimpliVity 325, a 1U server model featuring a single AMD EPYC CPU and all-flash storage.

In January 2018 HPE SimpliVity had a customer install base of approximately 2,000 customers worldwide. The number of employees working in the HPE SimpliVity division is unknown at this time.