The Failover Clustering Manager has been enhanced in Windows Server 2016 to incorporate Storage Spaces Direct (S2D). However, not all features are accessible by GUI. For some actions you rely quite heavily on PowerShell.

System Center Virtual Machine Manager (SCVMM) also provides a GUI to manage the storage besides the VM. SCVMM enables managing Storage QoS, the automation of deployment , VM placement and Storage Spaces Direct (S2D) deployment.

Windows Admin Center provides centralized management for S2D clusters including provisioning as well as real-time monitoring and alerting.