Nutanix is fully qualified for all VMware vSphere VAAI-NAS capabilities that include: Native SS for LC, Space Reserve, File Cloning and Extended Stats.
Nutanix is also fully qualified for MS Hyper-V 2012R2 / 2016 / 2019 ODX and TRIM.

UNMAP/TRIM support allows the Windows operating system to communicate the inactive block IDs to the storage system. The storage system can wipe these unused blocks internally.

RDMA is a network protocol that enables offloading storage processes from the server CPU. RDMA is strongly recommended when implementing S2D solution. It enables reading the hosts memory thus bypassing the OS. The result is a reduction of CPU usage, a decrease of network latency and an increase in throughput.

VAAI = Vmware vSphere APIs for Array Integration
ODX = Offloaded Data Transfers
RDMA = Read Direct Memory Access