Single cluster management is performed through the Nutanix Prism interface. Centralized management of multicluster environments is performed through Nutanix Prism Central (up to 12.500 VMs across all clusters). In addition Prism Pro features are accessed through the Prism Central interface.

AOS 5.8 introduces support for SAML user authentication for Prism Central. The Security Assertion Markup Language (SAML) is an open standard for exchanging authentication and authorization data between parties, in particular between an identity provider such as ADFS or OKTA and a service provider, which in this case is Prism Central. Limitations in this version:
- Only one identity provider can be configured.
- The role mapping is restricted to individual users; groups are not supported.
- Session timeouts are based on Prism Central only; the identify provider is not queried for session expiry.