Nutanix offers third-party drivers for OpenStack and include Acropolis compute, image, volume and network.

In June 2017 Nutanix Calm v1.0 was released as a follow-up the acqusition of Calm.io. Nutanix Calm adds native application orchestration and lifecycle management to Nutanix ECP. Calm decouples application management from the underlying infrastructure, thus enabling applications to be easily deployed into private or public cloud environments. The addition of advanced application management to the Nutanix platform turns common tasks into repeatable automations accessible to all IT teams, without giving up control across the infrastructure stack.

Nutanix Calm blueprints can be published directly for end user consumption through the Nutanix Marketplace, giving application owners and developers the ability to request IT services that can then be instantly provisioned.

Nutanix Calm provides role-based governance that limits user operations based on permissions. All activities and changes are centrally logged for end-to-end traceability and debugging, aiding security teams with key compliance initiatives.

Nutanix Calms latest version, 2.7.0, was released in August 2019 and is compatible with AOS 5.10/5.11 and Prism Central 5.10.6. Nutanix Calm 2.7.0 supports Nutanix AHV and VMware vSphere hypervisors. Nutanix Calm does not support Hyper-V.

Nutanix Calm requires a separate license.