SAS = 10k or 15k RPM = Medium-capacity medium-speed drives
SATA = NL-SAS = 7.2k RPM = High-capacity low-speed drives

VMware vSAN supports the use of 512e drives. 512e magnetic hard disk drives (HDDs) use a physical sector size of 4096 bytes, but the logical sector size emulates a sector size of 512 bytes. Larger sectors enable the integration of stronger error correction algorithms to maintain data integrity at higher storage densities.

VMware vSAN 6.7 introduced support for 4K native (4Kn) mode.

VMware vSAN 7.0 provides support for 32TB physical capacity drives.