vSphere uses natively integrated multi-path capability or can take advantage of vendor specific capabilities using vStorage APIs for Multipathing.
By default, ESXi provides an extensible multipathing module called the Native Multipathing Plug-In (NMP). Generally, the VMware NMP supports all storage arrays listed on the VMware storage HCL and provides a default path selection algorithm based on the array type. The NMP associates a set of physical paths with a specific storage device, or LUN. The specific details of handling path failover for a given storage array are delegated to a Storage Array Type Plug-In (SATP). The specific details for determining which physical path is used to issue an I/O request to a storage device are handled by a Path Selection Plug-In (PSP). SATPs and PSPs are sub plug-ins within the NMP module. With ESXi, the appropriate SATP for an array you use will be installed automatically. You do not need to obtain or download any SATPs.
PDL AutoRemove: Permanent device loss (PDL) is a situation that can occur when a disk device either fails or is removed from the vSphere host in an uncontrolled fashion. PDL detects if a disk device has been permanently removed. When the device enters this PDL state, the vSphere host can take action to prevent directing any further, unnecessary I/O to this device. With vSphere 5.5, a new feature called PDL AutoRemove is introduced. This feature automatically removes a device from a host when it enters a PDL state.